The Blues are in fine goalscoring form, having scored 11 goals in their last three fixtures, most recently dispatching five past Manchester City to progress to their sixth round of the FA Cup.
Despite their form, though, the reigning English champions’ domestic position remains dreary, making three points from the Saints a must.
Kurt Zouma and John Terry are out injured, leaving Hiddink with a difficult job deciding his defence.
So, who might the Dutchman select for his starting XI this weekend?
Take a look at talkSPORT’s predicted Chelsea line up versus Southampton by clicking the yellow arrow above, right.