Burnley forward Andre Gray serves the second game of a four-match ban for comments he made on Twitter in 2012.
Manager Sean Dyche could keep faith with the side which secured a 2-0 win over Watford on Monday night.
Arsenal will assess the fitness of midfielder Francis Coquelin, who has recovered quicker than expected from a knee injury.
Olivier Giroud, Aaron Ramsey, Per Mertesacker, Danny Welbeck and Carl Jenkinson remain sidelined.
MOTD COMMENTATOR’S NOTES
Guy Mowbray: “Arsene Wenger has huge respect, and maybe even a soft spot, for Burnley.
“After his last visit to Turf Moor, a 1-0 Gunners win in April last year, he praised Sean Dyche’s team and said it ‘would be a shame if they go down’.
“I suspect the sentiments remain the same today, with the Clarets’ economic prudence perhaps contributing to his admiration.
“They’ve been a little more extravagant for this latest return to the Premier League, breaking their transfer record twice in August, but Monday’s win over Watford showed that they’ve spent wisely on Jeff Hendrick and Steven Defour.
“Defour’s superb set-piece delivery gives them much more of a chance in games like this.”
Burnley manager Sean Dyche on Arsene Wenger: “Arsene, for me, is one of the top managers without a shadow of a doubt.
“A lot of respect goes out from me, as a young manager, looking at him and what he’s done… the way he puts a team together, the style, the manner.
“As managers we all understand the fan mentality, the thirst and desire to win and be successful, but from a manager’s point of view you have to scratch your head and wonder why he’s questioned at times.”
Arsenal manager Wenger on his 20 years in charge: “A lot has changed. The art of management has changed, the club has grown bigger, it is now a global club. Twenty years ago it wasn’t as big, or as expensive.
“Football has become popular, it’s become a world sport. Everything has changed and the pressure has intensified too.
“But what hasn’t changed is the solidarity inside the club. That’s always stayed the same.”
I like the look of Arsenal at the moment – they were very comfortable in their wins against Chelsea and Basel.
They will have to match Burnley’s work ethic but, if they do that, I think the Gunners will make it five wins in a row in all competitions.