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Brighton keeper Niki Maenpaa could make his league debut after David Stockdale (shin) was forced off in Friday’s 3-0 win over Nottingham Forest.
Defenders Connor Goldson and Uwe Hunemeier are still not ready to return to first-team action, with Bruno expected to continue at centre-back.
Rotherham’s on-loan midfielder Jake Forster-Caskey is ineligible to face his parent club.
Striker Izzy Brown could make his debut after joining on loan from Chelsea.
BBC Sussex’s Johnny Cantor
“Brighton will be looking to maintain their excellent home form in the Championship. Friday’s 3-0 victory over Nottingham Forest was their 12th league game unbeaten at the Amex, including last season’s play-off semi-final against Sheffield Wednesday.
“The Seagulls have coped well with the injuries to centre-backs Connor Goldson and Uwe Hunemeier and are yet to concede in their opening three games of the season.
“Chris Hughton will, however, be wary of their opponents, having admitted his side weren’t good enough after their 2-0 defeat by Rotherham last season.
“If they avoid complacency, retain their defensive strength and continue to threaten with the effervescent Anthony Knockaert, they should prove too strong for Alan Stubbs’ side.”
Brighton are unbeaten in their last seven home games against the Millers (four wins and three draws).
Neil Richardson and Lee Glover were on the scoresheet the last time Rotherham won away at Brighton in November 1997.
Glenn Murray has scored four goals in his last four Championship appearances; two for Brighton last time out against Nottingham Forest and two during a loan spell at Reading in December 2014.
The Millers are without a win in their last seven league games, drawing four and losing three.