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Brentford defender Callum Elder (knee) is a doubt as the Bees look to extend their three-match unbeaten run.
Left-back Rico Henry is out following shoulder surgery, while Alan Judge (broken leg) is a long-term absentee.
Preston full-back Greg Cunningham has recovered from a head injury suffered in the win over Cardiff in midweek.
Jermaine Beckford faces a check on his hamstring problem, while Stevie May and Calum Woods remain out with long-term knee injuries.
Brentford boss Dean Smith told BBC Radio London: “Preston had a very good win against Cardiff but we are full of confidence.
“We have got a good home record so far and the performances since the international break have been good.
“It will make other teams stand up and take notice of us. To go to Brighton and Aston Villa and take four points is a great achievement from the players.
“They want more and they know with the games coming up there is a great opportunity – but we have to keep performing at the same level.”
BBC Radio Lancashire’s Phil Cunliffe: “Tuesday’s win over Cardiff has provided some welcome respite from the early season problems, not least for the manager who upset some fans last weekend by suggesting they don’t attend matches if they were ‘fed up.’
“Grayson sought to clarify those comments in midweek and still has plenty of support on the terraces.
“The question is can North End build on their success at Brentford and will Grayson be bold enough to pick the same team and formation that turned over the Bluebirds?
“Forwards Jordan Hugill and Callum Robinson scored on Tuesday and the Lilywhites will need plenty more from those two if they’re to move into the comforts of mid-table.”
- The Bees are unbeaten in their last seven league meetings with Preston (W6 D1), winning the last five in a row.
- Preston haven’t kept a clean sheet in any of their last 10 league games against Brentford, last shutting them out in a goalless draw in February 1998.
- Since his first Championship game for Brentford in August 2014, Scott Hogan is averaging a goal every 82 minutes for the Bees (10 goals in 15 games).
- Preston have kept two clean sheets in their last four league games after keeping just two in the previous 20 beforehand.
- Brentford are unbeaten in their last seven home league games, winning five and drawing two.
- North End have either scored exactly twice or not at all in their last nine away league games, failing to score on four occasions.