Scott Hogan’s goal for Brentford was the difference in their match against Nottingham Forest.
Forest goalkeeper Stephen Henderson saved Hogan’s initial effort and Lewis Macleod’s follow-up before Hogan tapped home his first goal of the season.
Dean Smith’s Bees have now won back-to-back games at home with clean sheets.
Damien Perquis was sent off late on for Forest for a second yellow card and striker Britt Assombalonga wasted a one-on-one in injury time.
The victory for the hosts means they have won four games in a row at home in the second tier for the first time since 1951.
Brentford goalkeeper Daniel Bentley produced a number of second-half saves to secure three points, including his parry from former Southend team-mate Assombalonga.
Earlier, Macleod had hit the crossbar for the Bees while Hildeberto Pereira and Eric Lichaj went close for the visitors.
Head coach Philippe Montanier, who joined Forest in the summer, has seen his team suffer back-to-back Championship losses after their opening day win over Burton.