Darnell Fisher and Dominic Ball are set for their first games for Rotherham.
But captain Lee Frecklington (calf) is set to be out for a couple of weeks.
Defenders Kirk Broadfoot (hamstring) and Joe Mattock (knee) should be fit.
BBC WM’s Mark Regan: “Whether it was a direct result of the EFL Cup exit or not, Villa became active in the transfer market almost immediately.
“So now, after two games and two defeats to start their season, Villa face Rotherham at home and it’s a game that already feels like a must win.
“After Luton, there were worrying signs for Villa fans that the same old problems were still dogging the team. They were unable to deal with an energetic opposition and seemed to be unable to assert themselves after conceding the equaliser.”
BBC Radio Sheffield’s Rob Staton: “The Millers have conceded seven goals in their first two games and will be coming up against £12m Ross McCormack here – that could be a problem.
“That said, all the pressure is on the home team after their losing start to the new season. Rotherham will look to make a bad week even worse for Villa.”
Aston Villa have won three of their four home league meetings with the Millers (lost one), all played between 1960 and 1971.
Rotherham have lost six of their eight away clashes with Villa in all competitions (won two), with their most recent trip to Villa Park resulting in a 3-0 loss in the League Cup in August 2013.
These two sides met in the very first League Cup final in 1961, which was played over two legs – Villa won 3-2 on aggregate thanks to a 3-0 win in the second leg at Villa Park.
Aston Villa have now picked up just one point from their last 14 league games (drawn one, lost 13), dating back to February 2016.
Anthony Forde’s two assists in Rotherham’s season opener were as many as he had registered in his previous 24 league games beforehand.