Wenger has few options with Per Mertesacker and Gabriel both injured but is already being criticised by fans.
One angry Arsenal supporter held up a “Where’s our money” banner on Sunday, while others booed the team off.
Wenger is also still in the market for Lyon striker Alex Lacazette, but Arsenal are unwilling to pay £40m for him.
Goalkeeper Petr Cech has also leapt to the defence of Chambers and debutant Holding in the wake of Sunday’s game.
He said: “I thought they did really well. When you concede four goals then obviously you cannot be happy as a team because you should not concede four goals at home, but I thought it was a really good experience for them.”