Arsenal midfielder Alex Oxlade-Chamberlain has been ruled out for up to eight weeks with the knee injury he suffered against Barcelona last week.
Danny Welbeck is likely to be rested, having only just come back from a 10-month injury lay-off.
Swansea City are at full strength for their trip to the Emirates Stadium on Wednesday.
On-loan midfielder Leroy Fer could be handed his first start since joining from QPR in January.
MOTD COMMENTATOR’S NOTES
John Motson: “Arsenal’s poor performance against Manchester United has been roundly criticised by all and sundry, but everybody has got a bit carried away.
“While the focus has now turned to their trip to Tottenham on Saturday, this game with Swansea could be even more pivotal.
“If they don’t win, their title chances would be all but over.
“It’s not a game they can take lightly, either. Swansea have a good record at the Emirates, with two wins and a draw on their last three visits, and they gave Tottenham a good run for their money on Sunday.
“With three games to come against fellow relegation rivals, the Swans would love to go into those fixtures on the back of a morale-boosting result.”
WHAT THE MANAGERS SAY
Arsenal manager Arsene Wenger: “We want to transform the negatives into positives around us and create even more solidarity. Let’s not go overboard, we do not play to be relegated.
“We are playing to fight for the title. That’s why we have to put criticism in the right place.”
Swansea put up a good fight against Tottenham and Lukasz Fabianski made some great saves to keep them in it, but they still lost and it is hard to see them getting anything at Emirates Stadium.
To have any hope of winning the title, Arsenal quite simply have to win.